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Updated: Jun 26, 2026

Using Enzyme-based Biosensors to Measure Tonic and Phasic Glutamate in Alzheimer's Mouse Models
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药理上增加cGMP可以改善蛋白质稳定,并减少CMT1小鼠模型中的神经病变

Seth M Moore1, Joseph Gawron1, Mckayla Stevens2

  • 1Department of Biochemistry, Institute for Myelin and Glia Exploration, Jacobs School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, NY, 14203, USA.

Cellular and molecular life sciences : CMLS
|October 14, 2024
PubMed
概括

提高循环氨酸单酸盐 (cGMP) 水平可以激活蛋白质体,帮助错误折叠的蛋白质降解. 这种方法对治疗Charcot Marie Tooth神经病变和其他神经退行性疾病充满希望.

关键词:
查科特玛丽·图斯 (Charcot Marie Tooth) 是一个牙科学家.周围神经病变是一种神经病变.酸化是指酸化的方法.蛋白质酶体是一种蛋白质酶体.蛋白质降解 蛋白质降解cGMP的良好使用情况.

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