在中度创伤性脑损伤后,脑和脑净水摄入量的比较
Alex O Trofimov1, Kseniia A Trofimova1, Oxana V Semyachkina-Glushkovskaya2
1Department of Neurological Diseases, Privolzhsky Research Medical University, Nizhny Novgorod, Russia.
Advances in experimental medicine and biology
|October 14, 2024
概括
在中度创伤性脑损伤后患有创伤后缺血症的患者中,大脑氧化与净水吸收相关. 这一发现有助于理解脑损伤,并改善患者的治疗结果.
科学领域:
- 神经科学是一个神经科学.
- 放射学 放射学是一门学科.
- 临界护理医学 临界护理医学
背景情况:
- 中度创伤性脑损伤 (moTBI) 可能导致创伤后缺血 (PTI) 焦点.
- 评估大脑氧化率及其与组织变化的关系对于管理moTBI患者至关重要.
研究的目的:
- 在moTBI后患有PTI焦点的患者中,研究净吸水量 (NWU) 和大脑组织氧和 (SctO2) 之间的相关性.
主要方法:
- 输液计算断层扫描 (PCT) 和非对比CT用于评估72名moTBI患者.
- 大脑组织的氧和度 (SctO2) 用Fore-Sight 2030测量在额叶极 (FLP) 中.
- 净吸水量 (NWU) 由CT数据计算;统计学意义为P<0.05.
主要成果:
- 在FLP中的SctO2在61%至88%之间.
- 在PTI损伤上的SctO2为62% [55.4;72.1]和64% [58.5;73.7]在抵押方.
- 在没有焦点前叶损伤的患者中,在SctO2和NWU之间发现了显著的负相关性 (R = -0.780,p < 0.00001).
结论:
- 大脑组织的氧气和与PTI患者在moTBI后的净水吸收有显著的相关性.
- 这些发现强调了在创伤性脑损伤的背景下,氧化和组织水分之间的相互作用.
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