血清白蛋白在基于深度学习的预测认知功能数据在老年人使用基本血液测试中的重要性
Kenji Karako1, Takeo Hata2, Atsushi Inoue3
1Department of Human and Engineered Environmental Studies, Graduate School of Frontier Sciences, The University of Tokyo, Bunkyo City, Tokyo, Japan.
Advances in experimental medicine and biology
|October 14, 2024
概括
在血液测试中包括血清白蛋白可以改善老年人痴呆症风险预测. 这种营养标志物对于老年人准确的认知功能评估至关重要.
科学领域:
- 老年学是一门学科.
- 医学诊断 医学诊断 医学诊断
- 人工智能的人工智能
背景情况:
- 深度学习模型使用常规血液检测估计痴呆症风险.
- 血液检查可以表明生活方式疾病和与认知障碍相关的代谢障碍.
- 营养状况,特别是在脆弱的老年人中,可能会影响痴呆风险.
研究的目的:
- 评估包括血清白蛋白如何影响痴呆症风险预测的准确性.
- 评估营养状况标志物在认知功能估计中的作用.
- 为了在不同年龄组中比较带有和没有血清白蛋白的预测模型.
主要方法:
- 利用深度学习模型 (DLM) 来估计认知功能 (迷你心理状态检查 - MMSE).
- 采用了来自1287名医院患者的一般血液检测数据.
- 分析了65岁以上和65岁以下个体的数据,比较了带有和没有血清白蛋白的MMSE预测.
主要成果:
- 对于65岁以上的个体,包括血清白蛋白,将平均平方误差 (MSE) 从6.38降低到6.28.
- 在65岁以下的个体中,血清白蛋白提高了预测准确度,将MSE从5.33降低到4.62.
- 包括血清白蛋白在内,在各个年龄组中始终提高了预测准确性.
结论:
- 血清白蛋白是估计血液检测认知功能的重要变量,特别是在老年人中.
- 低血清白蛋白表示的营养不良会对老年人的认知功能产生不利影响.
- 纳入像血清白蛋白这样的营养标志物可以提高人工智能驱动的痴呆风险评估的准确性.
更多相关视频
07:22Assessment of Blood-brain Barrier Permeability by Intravenous Infusion of FITC-labeled Albumin in a Mouse Model of Neurodegenerative Disease
Published on: November 8, 2017
9.9K
12:28Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains
Published on: June 3, 2020
17.3K
相关概念视频
Serum Studies: Renal Function Tests
1
Renal function tests are crucial for assessing kidney health, monitoring disease progression, and evaluating the kidneys' efficiency in waste elimination, fluid balance, and electrolyte regulation. These tests offer critical insights into kidney function, even though routine measurements may appear normal until there is a significant decline in the glomerular filtration rate or GFR. Typically, signs of kidney impairment only become evident when the GFR falls to about 50% of its normal level.
1
Alzheimer's Disease: Overview
449
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
449
