在一般麻醉下保持石切位的患者下肢组织的血液体积和氧化量的变化
Miho Kijima1, Noriya Hirose2, Yuko Tomita1,3
1Division of Anesthesiology, Department of Anesthesiology, Nihon University School of Medicine, Tokyo, Japan.
Advances in experimental medicine and biology
|October 14, 2024
概括
在全身麻醉期间的石切位置可能会增加血液体积和大腿组织的氧化. 这项研究发现,在60分钟内,总血红蛋白,组织血红蛋白指数和组织氧化指数显著增加.
科学领域:
- 麻醉学 麻醉学
- 生理学 生理学 生理学
- 医疗器械 医疗器械
背景情况:
- 石切位通常用于外科手术.
- 在全身麻醉下对下肢循环的潜在影响需要调查.
- 近红外光谱学 (NIRS) 提供了一种非侵入性方法来评估组织血液动力学.
研究的目的:
- 评估石头切割位置对下肢循环的影响.
- 在全身麻醉期间测量血液体积和大腿组织中氧化的变化.
- 为了确定循环变化和患者/心肺呼吸因子之间的相关性.
主要方法:
- 使用近红外光谱 (NIRS) 来测量总血红蛋白度 (总Hb),组织血红蛋白指数 (nTHI) 和组织氧化指数 (TOI).
- 监测了24名接受全身麻醉的患者,在石切位上进行了60分钟的监测.
- 从基线分析了变化,并评估了与患者特征和心肺呼吸指数的相关性.
主要成果:
- 总Hb (+3.09 μmol/L),nTHI (+0.08 a.u.) 的显著增加被观察到. ) 和TOI (+2.25%) 在60分钟期间 (p < 0.05).
- 这些循环变化与患者背景因素或心肺呼吸指数之间没有发现显著的关联.
- 腿部组织循环显示出高血压的趋势.
结论:
- 在全身麻醉下的石切位置可能会诱导大腿组织循环中的高血压转移.
- 这些循环变化似乎独立于患者的人口统计和心肺呼吸状况.
- 进一步的研究可能会探索这些发现对手术患者的临床影响.
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