在心血管外科手术后患者的心肺运动测试期间,前额叶皮层中大脑氧化量的变化
Leo Washizawa1,2,3, Kentaro Iwata2, Ryuya Takimoto2
1Graduate School of Health and Welfare, Niigata University of Health and Welfare, Niigata, Japan.
Advances in experimental medicine and biology
|October 14, 2024
概括
心血管外科手术患者在运动期间显示脑前额叶皮层 (PFC) 的氧气供应减少. 这表明手术后大脑的氧化受损,影响运动能力.
科学领域:
- 心血管生理学心血管生理学
- 神经科学是一个神经科学.
- 医疗成像医学成像
背景情况:
- 氧化血红蛋白 (O2Hb) 和总血红蛋白 (THb) 在心肺运动测试 (CPX) 中随着运动负载而增加.
- 已知这种反应在慢性心力衰竭患者中受损.
- 心脏手术后急性阶段的大脑氧化变化还不清楚.
研究的目的:
- 在心血管外科手术后急性阶段的患者中,在CPX期间测量前额叶皮层 (PFC) 大脑氧化率.
- 为了研究心脏功能减弱对手术后大脑氧气供应的影响.
主要方法:
- 近红外光谱学 (NIRS) 用于测量PFC中的O2Hb,脱氧血红蛋白 (HHb),THb和区域大脑氧和度 (rSO2).
- 14名患者在术后护理和出院之间使用坡道协议 (10W/分钟) 进行了CPX.
- 从休息到峰值运动的时间进行了测量,比较休息,热身,厌氧值和峰值运动的值.
主要成果:
- 在高峰运动时,O2Hb和rSO2与休息相比显著下降.
- 与休息相比,HHb水平在运动高峰时显著增加.
- 在整个CPX中没有观察到THb水平的显著变化.
结论:
- 心血管外科手术后急性阶段的患者在运动期间显示PFC的氧气供应减少.
- 这种大脑氧化受损可能会导致这种患者群体的运动不耐受.
- 在临床环境中,NIRS是评估运动期间大脑氧化变化的宝贵工具.
关键词:
进行心肺运动测试,进行心肺运动测试.时间回应指数 (chronotropic response index) 是指时间回应指数.心血管外科手术后的情况.前额叶皮层前额叶皮层.可穿戴的近红外光谱学.更多相关视频
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