在中国成年人中,多重金属暴露与骨矿物质密度之间的关联
Gaojie Fan1,2, Qing Liu1,2, Mingyang Wu1,2
1Department of Maternal and Child Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, HangKong Road 13, Wuhan, 430030, Hubei, China.
Environmental geochemistry and health
|October 14, 2024
概括
暴露于多种金属,包括和,与中国成年人的骨矿物质密度 (BMD) 较低有关. 这种关联在男性中尤为明显,突出了潜在的公共卫生问题.
科学领域:
- 环境健康 环境健康
- 骨的新陈代谢 骨的新陈代谢
- 毒理学 毒理学 毒理学
背景情况:
- 之前对金属暴露和骨矿物质密度 (BMD) 的研究主要是检查单个金属.
- 了解混合金属暴露对BMD的影响对于公共健康至关重要.
研究的目的:
- 调查单个和多重金属暴露与中国成年人骨硬化之间的关联.
- 为了区分单个金属对骨健康的影响与联合金属负担的影响.
主要方法:
- 利用了来自武汉通治医院招募的2922名中国成年人的数据.
- 使用感应合血质谱法测量了21种金属的尿度.
- 通过双能X射线吸收测量来评估BMD,并采用线性回归和贝叶斯内核机器回归 (BKMR).
主要成果:
- 线性回归表明, (Cd) 和 (Sr) 与较低的BMD有显著的关联.
- BKMR揭示了21种金属的同时暴露对整体队列的BMD产生了负面影响,特别是在男性中.
- 在Cd和Sr暴露的最高四分位数中,有明显的负面关联与骨硬化.
结论:
- 对多种金属的联合暴露,而不仅仅是单个元素,在中国成年人中与骨硬化有害相关.
- 男人似乎特别容易受到金属共同暴露对骨矿物质密度的负面影响.
- 需要进一步的前性研究来阐明这些关联背后的机制.
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