实体器官移植后的大脑:一个21年的回顾性研究
Leah M Grant1, Pool J Tobar Vega1, Reena N Yaman2
1Division of Infectious Diseases, Mayo Clinic, Phoenix, Arizona, USA.
概括
实体器官移植接受者的脑是罕见但严重的. 心脏病和真菌是最常见的原因,真菌感染表明预后更差.
科学领域:
- 传染性疾病 传染性疾病
- 移植医学 移植医学
- 神经学 神经学
背景情况:
- 脑是固体器官移植 (SOT) 接受者的严重并发症,与高发病率和死亡率有关.
- 了解SOT患者脑的具体挑战对于改善结果至关重要.
研究的目的:
- 研究SOT接受者的脑的原因,临床特征,诊断方法,治疗方法和结果.
- 确定最常见的病原体和风险因素,与移植后脑相关.
主要方法:
- 进行了一项回顾性研究,涉及2000年1月至2021年6月期间被诊断患有脑的成年SOT接受者.
- 从三个主要的移植中心收集了数据,分析了患者人口统计,移植类型,病原体,诊断时间和治疗方法.
主要成果:
- 诺卡迪亚 (61.5%) 和真菌 (30.7%) 是39名患有脑的SOT患者中主要发现的病原体.
- 接受移植的接受者占大多数 (59%). 诊断的中位时间是SOT后的1.3年,真菌通常在第一年内被诊断出来.
- 死亡率显著,有28.2%的患者死于脑,总体所有原因死亡率为43.6%.
结论:
- 脑是一个不常见的,但严重的感染性并发症后SOT.
- 在这个人群中,心脏病和真菌感染是大多数脑的原因.
- 菌脑与特别糟糕的预后有关,强调了及时诊断和有针对性的治疗的必要性.
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