与等离子体和染色体移动遗传元素的基因内冲突推动了物种内自然转化的进化
Fanny Mazzamurro1,2, Jason Baby Chirakadavil3, Isabelle Durieux3
1Institut Pasteur, Université Paris Cité, CNRS UMR3525, Microbial Evolutionary Genomics, Paris, France.
PLoS biology
|October 14, 2024
概括
在Legionella pneumophila和Acinetobacter baumannii中,自然转化率差异很大,受移动遗传元素的遗传冲突的影响. 这些冲突塑造了细菌的进化和适应策略.
科学领域:
- 微生物学 微生物学
- 细菌遗传学 细菌遗传学
- 进化生物学 进化生物学
背景情况:
- 自然转化是一种由受体控制的关键细菌遗传交换机制.
- 了解它的进化动态对于细菌的适应性和病原性至关重要.
研究的目的:
- 在临床菌株的Legionella pneumophila和Acinetobacter baumannii中量化自然转化率.
- 研究进化模式和转化速率的决定因素,特别是遗传冲突的作用.
主要方法:
- 对786种L. pneumophila和496种A. baumannii菌株的自然转化率的量化.
- 对转化速率的家族遗传学分析和全基因组关联研究 (GWAS) 以确定遗传关联.
- 研究移动遗传元素 (MGE) 和天生的防御系统对转变的影响.
主要成果:
- 转化速率在6个数量级上有显著的变化,许多菌株是不可转化的.
- 环境A. baumannii菌株的转化率高于临床菌株.
- 频繁过渡到非可转化与MGEs有关,可转化菌株具有较少的MGEs和先天防御系统影响率.
结论:
- 细菌和MGEs之间的遗传冲突是自然转化的进化的主要驱动力.
- 像CRISPR-Cas这样的自适应性防御系统可以在保护MGEs的同时保持自然转变.
- 尽管生活方式不同,但L. pneumophila和A. baumannii表现出类似的趋势,这表明这些进化原理的广泛适用性.
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