来自印度西部的胎儿生长模式与Intergrowth-21st之间的比较
Arun Kinare1, Priscilla Joshi1, Kamini Dangat2
1Department of Radiodiagnosis, Bharati Medical College and Hospital, Bharati Vidyapeeth (Deemed to be University), Pune, Maharashtra, India.
PloS one
|October 14, 2024
概括
印度妇女的胎儿生长与Intergrowth-21st标准不同,一些测量更小. 这表明印度需要特定于人口的胎儿生长参考,以准确识别胎儿生长限制.
科学领域:
- 产科和妇科 产科和妇科
- 胎儿医学 胎儿医学
- 人口健康 人口健康
背景情况:
- 准确的胎儿生长评估对于确定胎儿生长限制 (FGR) 至关重要.
- 现有的胎儿生长标准,如Intergrowth-21st,可能不能完全代表多样化的人口.
- 纵向数据收集对于了解胎儿生长轨迹至关重要.
研究的目的:
- 在印度人口中生成纵向胎儿生长数据.
- 将印度胎儿生长参数与Intergrowth-21st标准进行比较.
- 评估印度胎儿的Intergrowth-21st标准的适用性.
主要方法:
- 一项前性纵向观察性研究 (REVAMP) 收集了2017-2022年的胎儿生物识别数据.
- 测量包括特定妊娠年龄的冠-长 (CRL),双双脚直径 (BPD),头周长 (HC),腹周长 (AC) 和股骨长 (FL).
- 位置,尺度和形状 (GAMLSS) 的通用添加模型被用来创建胎儿生长百分曲线,与Intergrowth百分相比较.
主要成果:
- 健康的印度胎儿在11-14周的CRLZ分数较低,在18-22和32-35周的BPDZ分数较低.
- 头周长 (HC) Z-分数在18-22周时可比较,但在32-35周时更小.
- Femur 长度 (FL) 是可比或更大,而腹周 (AC) Z-分数因妊娠年龄而异.
结论:
- 健康和低风险的印度妇女的胎儿尺寸和生长轨迹与Intergrowth-21st标准显著不同.
- 这些发现凸显了将全球标准应用于当地人口的潜在局限性.
- 需要进行一项更大规模,更具代表性的印度研究,以建立特定人群的胎儿生长参考值,以改进FGR检测.
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