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相关概念视频

Defense Against Bacterial Pathogens01:31

Defense Against Bacterial Pathogens

1.4K
The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
1.4K
Diversity of Antigen Receptors01:28

Diversity of Antigen Receptors

534
Antigen receptors are essential components of the immune system crucial in defending the body against foreign invaders. These receptors are present on the surface of B and T cells, enabling them to recognize antigens and mount an appropriate immune response.
Before encountering any antigen, lymphocytes express these receptors. On B cells, the antigen receptor is a membrane-bound antibody molecule called BCR; on T cells, it is a T cell receptor or TCR. B and T cell receptors are composed of two...
534
Tagging and Fusion Proteins01:24

Tagging and Fusion Proteins

6.6K
Proteins are involved in several cellular processes and biochemical reactions. Analyzing a specific protein of interest requires it to be isolated from the other proteins in the cell. This is achieved by overexpressing the specific gene in a suitable host to produce large quantities of the target protein. A tag or label is recombined with the gene to produce a fusion protein containing the target protein and the tag. The tags on these fusion proteins can then be used for easy detection and...
6.6K
Antigens Involved in Adaptive Immunity01:26

Antigens Involved in Adaptive Immunity

465
An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and...
465
Antibody Actions01:26

Antibody Actions

1.1K
Antibodies, or immunoglobulins, are critical players in the immune system's arsenal against invading pathogens. Produced by B cells and plasma cells, their primary role is to detect and bind to specific antigens, molecules found on the surface of pathogens like bacteria or viruses. Beyond antigen recognition, antibodies perform several vital functions that contribute to immune defense.
Neutralization
Antibodies can bind to pathogens, preventing them from infecting host cells. This process...
1.1K
Humoral Immune Responses01:36

Humoral Immune Responses

72.0K
Overview
72.0K

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相关实验视频

Updated: Jun 10, 2025

Generation of Human Chimeric Antigen Receptor Regulatory T Cells
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Generation of Human Chimeric Antigen Receptor Regulatory T Cells

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使用高 afinity 化学标签对病原细菌的免疫系统的招募.

Yael Belo1, Einav Malach1, Zvi Hayouka1

  • 1Institute of Biochemistry, Food Science and Nutrition, The Robert H. Smith Faculty of Agricultural, Food & Environment, The Hebrew University of Jerusalem, Rehovot 76100, Israel.

Bioconjugate chemistry
|October 14, 2024
PubMed
概括

科学家们开发了一种新的仿制剂来对抗免疫逃避细菌. 该剂标记病原体,招募免疫系统消除它们,显示90%的根除耐药性大肠杆菌.

科学领域:

  • 免疫学 免疫学 免疫学
  • 微生物学 微生物学
  • 生物技术是生物技术.

背景情况:

  • 病原体发展出免疫逃避策略,阻碍宿主防御.
  • 目前的治疗方法面临来自耐药细菌菌株的挑战.
  • 需要新的治疗方法来克服病原体免疫逃避.

研究的目的:

  • 开发一种新的化学药物,用于向和消灭逃避免疫系统的病原体.
  • 为了创建一个工具,招募宿主的免疫系统对抗耐药细菌.
  • 为了证明-蛋白结合物的有效性,增强补充介导的细菌杀死.

主要方法:

  • 一种酸细菌结合剂与C3b补充系统激活蛋白质的结合,以创建一种化学剂.
  • 评估C3b化学标签的活性和结合 afinity 补充蛋白C5.5.
  • 在体外测试化学剂对抗抗补剂耐药性大肠杆菌 (E. coli) 的疗效.

主要成果:

  • 开发出来的仿制C3b标签保留了其功能活性,并表现出强烈的C5.5结合.
  • 嵌合剂成功地根除了90%的抗补剂*大肠杆菌*细菌细胞.
  • 这项研究表明,在用仿制剂治疗的病原体中,补体敏感性增强.

更多相关视频

Non-Viral Engineering of Primary Human T Cells via Homology-Mediated End-Joining Targeted Integration of Large DNA Templates
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Non-Viral Engineering of Primary Human T Cells via Homology-Mediated End-Joining Targeted Integration of Large DNA Templates

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139
Measuring TCR-pMHC Binding In Situ using a FRET-based Microscopy Assay
19:05

Measuring TCR-pMHC Binding In Situ using a FRET-based Microscopy Assay

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相关实验视频

Last Updated: Jun 10, 2025

Generation of Human Chimeric Antigen Receptor Regulatory T Cells
10:29

Generation of Human Chimeric Antigen Receptor Regulatory T Cells

Published on: January 3, 2025

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Non-Viral Engineering of Primary Human T Cells via Homology-Mediated End-Joining Targeted Integration of Large DNA Templates
06:10

Non-Viral Engineering of Primary Human T Cells via Homology-Mediated End-Joining Targeted Integration of Large DNA Templates

Published on: May 9, 2025

139
Measuring TCR-pMHC Binding In Situ using a FRET-based Microscopy Assay
19:05

Measuring TCR-pMHC Binding In Situ using a FRET-based Microscopy Assay

Published on: October 30, 2015

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结论:

  • 一种新奇的仿制剂通过利用补体系统有效地准和消除免疫逃避细菌.
  • 这种方法为对抗抗生素耐药性细菌感染提供了一个有前途的新治疗策略.
  • 这些发现为开发有选择性和强效的抗菌剂铺平了道路.