体在心脏纤维化中的新兴作用
Kellina Maduray1, Jingquan Zhong1,2
1State Key Laboratory for Innovation and Transformation of Luobing Theory; Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese National Health Commission and Chinese Academy of Medical Sciences; Department of Cardiology, Qilu Hospital of Shandong University, Shandong University, Jinan, Shandong, China.
American journal of physiology. Cell physiology
|October 14, 2024
概括
体 (KBs) 可能通过复杂的机制影响心脏纤维化. 新出现的证据表明,KBs可以减轻炎症和氧化应激,可能为心血管健康带来好处.
科学领域:
- 心血管研究研究心血管研究
- 代谢途径 代谢途径
- 纤维化机制 纤维化机制
背景情况:
- 心脏纤维化,以过度的细胞外基质沉积为标志,是心血管疾病的关键因素.
- 体 (KB) 和β-基酸盐 (β-OHB) 一样,具有潜在的心脏保护作用.
- 对于KBs在心脏纤维化中的特定作用尚不清楚.
研究的目的:
- 审查有关体和心脏纤维化之间关系的现有文献.
- 探索 KBs 影响心脏纤维化通路的潜在机制.
- 综合当前的理解,并确定有关KB和心脏纤维化方面的知识差距.
主要方法:
- 对调查体和心脏纤维化研究的综合文献综述.
- 分析涉及细胞组件 (纤维细胞,免疫细胞) 和细胞外基质的拟议机制.
- 检查KB对氧化应激,炎症和细胞信号传递等纤维化过程的影响.
主要成果:
- 有证据表明存在复杂的相互作用,一些研究表明KBs具有益纤维菌作用,而另一些研究则强调KBs的抗纤维菌潜力.
- KBs可以通过影响心脏纤维细胞,免疫细胞和细胞外基因组件来调节纤维细胞通路.
- KBs似乎可以减轻氧化应激和炎症,这是纤维细胞重塑的核心过程.
结论:
- KB代谢和心脏纤维化之间的关系是复杂的,需要进一步研究.
- KBs可以通过减少炎症和氧化应激来提供治疗心脏纤维化管理的途径.
- 进一步的研究至关重要,以充分阐明KBs在预防和治疗心脏纤维化和相关心血管疾病中的有益作用.
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