早期暴露于全身麻醉和神经行为缺陷之间的关系
Jinnan Xu1, Fan Wang2, Yi Gao2
1Department of Anesthesiology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Developmental neuroscience
|October 14, 2024
概括
儿童的全身麻醉可能会影响神经行为发展. 本综述检查了麻醉与ADHD和自闭症等疾病之间的联系,为安全的儿科麻醉使用提供了指导.
科学领域:
- 儿科麻醉学 儿科麻醉学
- 神经发育障碍 神经发育障碍
- 毒理学 毒理学 毒理学
背景情况:
- 整体麻醉对于儿科手术至关重要.
- 对儿童早期麻醉暴露的潜在神经毒性影响存在担忧.
- 有限的研究解决了与神经认知效应相比的神经行为影响.
研究的目的:
- 审查关于全身麻醉和儿童5种神经行为障碍的临床试验数据.
- 综合对麻醉药物毒理学机制影响神经行为的基础研究.
- 为安全的儿科麻醉实践提供指导.
主要方法:
- 对临床试验结果的全面分析.
- 麻醉毒理学基础研究的综合.
- 专注于精细运动障碍,ADHD,冲动控制,自闭症谱系障碍和发育协调障碍.
主要成果:
- 目前关于神经行为结果的研究范围有限.
- 麻醉剂可能具有影响神经行为变化的毒理机制.
- 有证据表明,全身麻醉与特定的神经行为障碍之间存在潜在联系.
结论:
- 在儿童的全身麻醉中,由于潜在的神经行为风险,需要谨慎使用.
- 需要进一步的研究才能充分理解麻醉对神经发育的影响.
- 本综述强调儿童患者谨慎使用麻醉剂.
相关概念视频
Stages of General Anesthesia
379
Various sedation levels offer significant advantages in facilitating procedural interventions for patients undergoing medical or invasive surgical procedures. These levels span from anxiolysis to general anesthesia, providing a spectrum of sedative effects to cater to specific patient needs. Anxiolysis reduces anxiety and is achieved through minimal sedation, enabling patients to remain awake and responsive while feeling more at ease during the procedure. This level can benefit minor...
379
General Anesthesia: Overview
196
Anesthesia is a medical procedure that uses drugs for CNS suppression to enable painless surgeries and procedures. The selection of anesthetics is influenced by their pharmacokinetic properties, side effects, and patient characteristics. Various types of anesthesia include general, local, regional, spinal, and inhalational.
General anesthesia induces unconsciousness in the whole body, while the others target specific areas or sensations. It is administered to minimize adverse effects, maintain...
General anesthesia induces unconsciousness in the whole body, while the others target specific areas or sensations. It is administered to minimize adverse effects, maintain...
196
Local Anesthetics: Adverse Effects
394
While local anesthetics are generally safe and well-tolerated, they can occasionally cause adverse effects that vary in severity. Local anesthetics can induce toxicity at two distinct levels. They can either produce local effects through direct contact with the neural elements or be absorbed into the bloodstream from the injection site, leading to systemic effects.
Once absorbed into the systemic circulation, local anesthetics can affect the organs that depend on the functioning of sodium...
Once absorbed into the systemic circulation, local anesthetics can affect the organs that depend on the functioning of sodium...
394


