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在缺血性中风患者中,中风后发作的发生率和危险因素

Emma M Federico¹, Kate Carroll², Margaret McGrath²

¹Stroke & Applied NeuroScience Center, University of Washington, Seattle WA, USA; Stritch School of Medicine, Loyola University Chicago, Maywood IL, USA; Department of Neurological Surgery, University of Washington, Seattle WA, USA.

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association

|October 14, 2024

概括

脑卒中后发作 (PSS) 影响8.8%的缺血性脑卒中患者. 关键预测因素包括年轻的年龄,皮层参与和更高的NIHSS分数,有助于风险分层,以获得更好的患者结果.

科学领域:

神经学神经学
脑卒中医学脑卒中医学
发病学 (Epileptology) 是一个专业的学科.

背景情况:

脑卒中后发作 (PSS) 是缺血性脑卒中的一个重要并发症,有助于增加发病率和死亡率.
对于PSS发生率和相关风险因素的全面了解仍然有限.
这项研究调查了在单一综合性中风中心中PSS的发生率和预测因素.

研究的目的:

确定急性缺血性中风后成年患者中中风后发作 (PSS) 的发生率.
为了确定与PSS发展相关的重大风险因素.
为改善风险分层和潜在的预防策略提供数据.

主要方法:

对1211名成年急性缺血性中风患者 (2018-2022) 的回顾性队列研究.
排除标准包括先前的史,并发性中风或早期死亡率.
用多变量逻辑回归和Cox比例危险分析来确定PSS预测因素.

主要成果:

后遗症综合征的总发病率为8.8% (n=106),其中53.8%被归类为早期 (≤7天),46.2%被归类为晚期 (>7天).
双变量分析显示年轻的年龄,糖尿病,更高的NIHSS,低的阿尔伯塔中风计划早期计算机断层扫描得分,皮质参与和出血转变是潜在的风险因素.
多变量考克斯分析确定皮质参与 (HR: 2.31),NIHSS ≥21 (HR: 1.82) 和年轻年龄 (HR: 0.97) 是PSS的显著预测因素.

结论:

脑卒中后发作 (PSS) 发生在8.8%的缺血性脑卒中患者中.
对于PSS的显著预测因素包括出血转变,皮质参与,NIHSS得分升高和患者年龄较小.
这些发现突出了识别PSS高风险个体的关键因素.

关键词:

发生出血发生出血缺血性中风是因为缺血性中风.风险因素风险因素发作发作发作

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