红细胞分布宽度和急性缺血性中风患者的结果
Leonor Ribeiro Dias1, João Pedro Ramalho Gonçalves2, Juliana Patrícia Figueiras Ferreira1
1Department of Clinical Neurosciences and Mental Health, Faculty of Medicine of University of Porto, Porto, Portugal; Department of Neurology, Centro Hospitalar Universitário São João, Porto, Portugal.
概括
红细胞分布宽度 (RDW) 并没有预测急性缺血性中风 (AIS) 患者在90天内的功能结果或死亡率. 这种生物标志物不是可靠的预后指标AIS患者在调整混因素后.
科学领域:
- 神经学 神经学
- 生物标志物 生物标志物
- 临床医学 临床医学
背景情况:
- 急性缺血性中风 (AIS) 的预后对于患者的管理至关重要.
- 红细胞分布宽度 (RDW) 与各种疾病和死亡率有关.
- 作为AIS严重程度和结果的独立预测因素,RDW的作用需要进一步调查.
研究的目的:
- 评估红细胞分布宽度 (RDW) 作为急性缺血性中风 (AIS) 患者功能结果和90天死亡率的独立预测指标.
主要方法:
- 患有AIS的患者根据入院红细胞分布宽度 (RDW) 季度分为四组.
- 功能性结局 (修改的兰金尺度) 和90天死亡率被前性评估.
- 进行了单变量和多变量逻辑回归分析,以控制潜在的混因素.
主要成果:
- 较高的红细胞分布宽度 (RDW) 四分位数与年龄较大,血红蛋白较低,C反应蛋白和BNP水平较高有关.
- 单变量分析表明,最高RDW四分位数与较差的功能结果和死亡率之间存在关联,但这并不重要.
- 经过对混因素进行调整后,多变量分析显示红细胞分布宽度 (RDW) 与功能独立或90天死亡率之间没有显著的关联.
结论:
- 红细胞分布宽度 (RDW) 并不是急性缺血性中风 (AIS) 患者功能结果或90天死亡率的独立预测指标.
- 在AIS中红细胞分布宽度 (RDW) 的预后值需要进一步验证,因为它在调整混变量后没有意义.
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