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基于解剖学亚型的乳外帕杰特病潜在恶性查的推指南

Nour Kibbi¹, Joshua L Owen², Brandon Worley³

¹Department of Dermatology, Stanford University School of Medicine, Palo Alto, California.

Journal of the American Academy of Dermatology

|October 14, 2024

概括

乳外帕杰特病 (EMPD) 查腺癌应以解剖位置为指导. 周围的EMPD与内部癌症的相关性更高,需要进行彻底的查.

科学领域:

在瘤学瘤学.
皮肤病学皮肤病学
胃肠病学胃肠病学

背景情况:

乳外帕杰特病 (EMPD) 可能表明潜在的内部腺癌 (次要EMPD).
EMPD亚型与腺癌之间的关联,以及查的影响,需要进一步澄清.

研究的目的:

确定与EMPD亚型相关的腺癌的发病率和类型.
提出一种基于证据的查算法,用于检测潜在的腺癌.

主要方法:

1990年1月至2022年11月期间发表的关于EMPD的122项研究的系统文献综述.
多学科专家小组对腺癌查建议的审查.

主要成果:

周围的EMPD与腺癌 (主要是结直肠癌) 有25%的关联.
阴茎和阴道EMPD与腺癌 (主要是生殖尿道) 有6%的关联.
查协议因EMPD位置而异,包括结肠镜检查,尿细胞检查,CT扫描,乳房镜检查和PSA检查.

结论:

在EMPD患者中查腺癌的查策略必须根据EMPD的解剖位置进行调整.
对EMPD的解剖学亚型是指导适当和有效的查协议的关键.

关键词:

腺癌瘤是一种腺癌.癌症查癌症查乳房外的帕杰特病 (Paget's disease) 是一种疾病.二次的EMPD是什么意思

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