瘤血栓患者的治疗方法和结果:一项回顾性队列研究
Sean Hui1, Khalid Zeid2, Roger Kou1
1Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada.
Journal of thrombosis and haemostasis : JTH
|October 14, 2024
概括
在瘤血栓患者中使用抗凝剂并没有显著改变新的静脉血栓塞栓症 (VTE),出血或死亡率等结果. 需要进一步的研究来澄清抗凝剂在管理瘤血栓和相关风险中的作用.
科学领域:
- 在瘤学瘤学.
- 血液学 血液学 血液学
- 血管医学 血管医学
背景情况:
- 瘤血栓形成与静脉血栓栓塞 (VTE) 风险增加和患者预后较差有关.
- 在瘤血栓患者中,抗凝治疗的最佳使用和影响仍然不完全理解.
研究的目的:
- 调查在被诊断患有瘤血栓的患者中使用抗凝剂.
- 评估抗凝药与关键临床结果之间的关联,包括血栓形成,出血和死亡率.
主要方法:
- 进行了一项回顾性队列研究,涉及211名在2019年至2022年期间被诊断患有瘤血栓的患者.
- 在12个月的随访期内评估了结果,包括新的VTE,严重出血和死亡率.
- 在接受抗凝血药的患者和没有接受抗凝血药的患者之间进行了比较,死亡被认为是竞争的风险.
主要成果:
- 对50.2%的患者给予抗凝药,通常用于瘤血栓,涉及主要静脉或并发性VTE.
- 肝细胞癌是最常见的癌症类型,静脉最常受到影响.
- 在服用抗凝血剂和未服用抗凝血剂组之间,在12个月的新型静脉动脉突发症 (11.4%),大出血 (36.6%) 或死亡率 (52.5%) 的累积发病率上没有显著差异.
结论:
- 患有瘤血栓的患者面临着风险相当大的VTE,出血和死亡率.
- 目前的研究表明,抗凝固药在这个患者群体中不会显著改变这些结果.
- 需要进一步研究以确定抗凝剂在瘤血栓管理中的确切作用和益处.
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