在参加PrEP服务的人群中进行乙型肝炎病毒查的挑战和机会:一项追溯流行率研究
Bianca Monti1, Roberto Rossotti2,3, Fabiana D'Aloia1
1School of Medicine, University of Milano-Bicocca, Monza, Italy.
乙型肝炎病毒 (HBV) 感染在低患病率地区的暴露前预防 (PrEP) 用户中不常见,但查至关重要. 在PrEP服务中进行HBV查可以识别感染并指导疫苗接种策略.
科学领域:
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
- 流行病学 流行病学
背景情况:
- 使用艾滋病毒预防的emtricitabine/tenofovir进行暴露前预防 (PrEP) 引发了关于乙型肝炎病毒 (HBV) 重新激活或治疗冗余的担忧.
- 需要现实世界的数据来了解PrEP用户中的HBV流行率,特别是在低流行率的环境中.
研究的目的:
- 评估意大利北部参加PrEP服务的人群中的HBV患病率.
- 为了评估这一群体的HBV疫苗接种 (初级或强剂) 的必要性,尽管先前的儿童疫苗接种.
- 为了确定与使用PrEP的HBV暴露相关的风险因素.
主要方法:
- 在意大利北部的三个服务中对2152名PrEP参与者的回顾性分析.
- 评估HBV表面抗原 (HBsAg) 和抗体状态.
- 二元逻辑回归分析以确定HBV暴露的风险因素,包括年龄,性别,出生地和chemsex使用.
主要成果:
- 患有HBsAg阳性的个体的患病率为0.46% (2152人中有10人).
- 与12岁接种疫苗的人相比,在出生时接种疫苗的个体中观察到需要HBV强剂量的可能性更高.
- 增加年龄和非意大利出生与先前HBV暴露的风险更高有关.
结论:
- 虽然不常见,但在低患病率国家的PrEP使用者中应考虑和管理HBV感染.
- 在PrEP服务中对HBV的查为提高疫苗接种覆盖率和预防性护理提供了机会.
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