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Updated: Jun 10, 2025

Author Spotlight: A Computational Approach to Decipher Amino Acid Preferences in Multispecific Protein-Protein Interactions
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蛋白质相互作用亲和力和特异性的遗传结构

Alexandra M Bendel1,2,3, Andre J Faure4,5, Dominique Klein1

  • 1Friedrich Miescher Institute for Biomedical Research (FMI), Basel, Switzerland.

Nature communications
|October 14, 2024
PubMed
概括

大多数突变广泛影响蛋白质结合亲和力,而罕见的突变改变了特异性. 特异性来自于残留物促进目标和防止目标外相互作用,揭示了蛋白质家族中的分布式编码.

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