在精神分裂症患者中,具有持续的听觉幻觉的个体内结构共变网络
Xu Shao1,2, Honghong Ren3, Jinguang Li4
1Department of Psychiatry, Zhejiang University School of Medicine Sir Run Run Shaw Hospital, Hangzhou, Zhejiang, China.
Schizophrenia (Heidelberg, Germany)
|October 14, 2024
概括
结构性大脑网络变化与精神分裂症的听觉幻觉有关. 持续的听觉幻觉与特定大脑区域的网络效率和连接性发生变化相关,为该疾病的神经生物学提供了新的见解.
科学领域:
- 神经成像是一种神经成像.
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
背景情况:
- 精神分裂症的听觉幻觉与皮质形态变化有关,但大脑网络的改变仍未得到充分研究.
- 了解结构共变网络的特性对于阐明听觉幻觉的神经基础至关重要.
研究的目的:
- 在精神分裂症患者中构建个体内结构共变网络,包括持久性听觉幻觉 (pAH) 和没有持久性听觉幻觉 (pAH).
- 确定与持续的听觉幻觉相关的网络变化及其与临床症状的相关性.
主要方法:
- 从90名患有pAH的精神分裂症患者,55名没有AH的精神分裂症患者和83名健康对照患者获得T1加权的MRI图像.
- 基于基于voxel的灰色物质体积和形态变异相似性的结构共变网络的构建.
- 使用ANCOVA对全球和本地网络指标进行比较,并通过基于网络的统计数据进行边缘分析;与临床得分进行相关性分析.
主要成果:
- 与对照组相比,这两组精神分裂症患者在左侧中枢上方前额回路中表现出较低的节点效率.
- 与非pAH和对照组相比,pAH组在顶部圈和右侧胰岛的左极的节点效率显著降低,右侧胰岛的中心度降低.
- 在pAH组中发现了一个由上环左极中心的结构共变性减少的子网络. 网络指标 (集群系数和小世界性) 与pAH组的PANSS积极得分负相关.
结论:
- 精神分裂症患者患有持续的听觉幻觉,表现出明显的结构性大脑网络变化,特别是在时间和岛屿区域.
- 这些发现凸显了网络层面分析对于理解听觉幻觉的神经生物学基础的重要性.
- 这项研究为网络层面的听觉幻觉背后的结构架构提供了新的见解.
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