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Updated: Jun 10, 2025

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在11q13.3处的功能变体rs9344调节了多发性骨髓瘤中CCND1的表达,具有t(11;14)

Hongwei Tang1, Huihuang Yan2, Suganti Shivaram1

  • 1Division of Hematopathology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.

Leukemia
|October 14, 2024
PubMed
概括

通过增加CCND1基因表达,rs9344 G等位基因与患多发性骨髓瘤 (MM) 的风险更高有关. 这种遗传变异影响了t(11;14) 转位,这是MM发展的关键因素.

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