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Updated: Jun 10, 2025

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表面活性剂辅助湿颗粒基矩阵片,没有特殊添加剂:延长模型BCSII类二的系统暴露

Rahat Shamim1, Sana Shafique2, Khalid Hussain3

  • 1Punjab University College of Pharmacy, University of the Punjab, Lahore, 54000, Pakistan.

AAPS PharmSciTech
|October 14, 2024
PubMed
概括

这项研究开发了使用表面活性剂辅助湿颗粒剂的持续释放烯片. 优化的配方 (MT2) 改善了生物可用性,并维持了24小时的治疗药物水平,使得每天服用一次剂量成为可能.

关键词:
溶解溶解是一种凯托普罗芬是一种酸盐.矩阵片是指一个矩阵片.药物动力学 药物动力学溶解度 溶解度 溶解度 溶解度表面活性剂辅助的湿颗粒处理.

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Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...
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