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在移植计划中患有自体主导多囊性病的患者的本源性切除术:长期单中心经验
Pavel Navratil1,2, Jiri Chalupnik3, Tomas Merkl3,4,5
1Department of Urology, University Hospital Hradec Kralove, Sokolska 581, 500 05, Hradec Králové, Czech Republic. pavel.navratil2@fnhk.cz.
International urology and nephrology
|October 14, 2024
概括
自体主导多囊性病 (ADPKD) 患者进行移植 (KT) 的原生切除术 (NN) 显示,计划程序具有更好的结果. 急性本地切除术与更高的并发症率有关,强调了针对ADPKD管理的量身定制的外科治疗方法.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 手术瘤学手术瘤学
- 遗传学 是一个遗传学.
背景情况:
- 自体主导多囊性病 (ADPKD) 是末期病的主要遗传原因.
- 原生切除术 (NN) 是一种有时需要在ADPKD患者,特别是接受移植 (KT) 患者手术干预的手术.
研究的目的:
- 评估自身主导性多囊性病 (ADPKD) 患者本源性切除术 (NN) 的指示,程序和结果.
- 分析影响移植中心ADPKD患者手术管理和NN结果的因素.
主要方法:
- 对152名ADPKD患者的回顾性分析,这些患者在1999年至2023年期间接受了移植 (KT) 和本地切除术 (NN).
- 根据NN紧急情况 (急性/计划) 和类型 (单边/双边) 分类患者,以比较手术参数和结果.
主要成果:
- 在152名患者中,89人 (58.6%) 患有NN,主要是单边的 (64%).
- 与计划的NN相比,急性NN与更长的手术,增加的血液损失和显著更高的术后并发症率 (23.8%单边,28.6%双边) 与计划的NN相比 (2.9%单边,4.3%双边) 有关.
结论:
- 自体主导多囊性病 (ADPKD) 患者的计划性原生切除术 (NN) 与急性NN相比,与更好的结果和更低的并发症率有关.
- 这些发现强调了在ADPKD中对NN进行仔细的外科规划和患者选择的重要性,以优化结果并最大限度地降低风险.
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