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心血管疾病和尿酸水平与大动脉动脉瘤的关联:双边孟德尔随机化研究
Yuanyuan Xiao1, Tao Xiang2,3
1Department of Emergency, The Third People's Hospital of Chengdu, Chengdu, Sichuan, China.
Scientific reports
|October 14, 2024
概括
冠状动脉疾病和心肌梗塞因果关系增加了大动脉动脉瘤和腹部大动脉动脉瘤的风险. 这些情况与胸前大动脉动脉瘤或尿酸水平之间没有发现因果关系.
科学领域:
- 心血管遗传学 心血管遗传学
- 大动脉疾病 大动脉疾病
- 流行病学 流行病学
背景情况:
- 冠状动脉疾病 (CAD) 和心肌梗塞 (MI) 是全球主要的死亡原因.
- 大动脉动脉瘤 (AA),包括腹部 (AAA) 和胸部 (TAA) 类型,以及大动脉剖析 (AD) 代表严重的血管疾病.
- 在CAD/MI和各种大动脉病理,包括尿酸水平之间的病因关系,仍然不完全理解.
研究的目的:
- 研究冠状动脉疾病 (CAD),心肌梗塞 (MI) 和尿酸水平与大动脉动脉瘤 (AA),腹部大动脉动脉瘤 (AAA),胸前大动脉动脉瘤 (TAA) 和大动脉剖析 (AD) 之间的潜在因果关系.
- 采用孟德尔随机化 (MR) 来评估欧洲祖先的个体中的这些因果关系.
主要方法:
- 使用全基因组关联研究 (GWAS) 数据对CAD,MI和尿酸水平进行双样本孟德尔随机化 (MR) 分析.
- 对AA,AAA,TAA和AD的遗传仪器来自FinnGen队列.
- 主要分析采用了反变量加权 (IVW) 方法,灵敏度分析包括MR-Egger,加权中位数MR和MR-PRESSO;MR-Egger截取和Cochran的Q统计评估了分别的变性和异质性. 进行双向MR以解决反向因果关系.
主要成果:
- 在CAD/MI和AA (OR: 1.309; 95%CI: 1.150-1.490) 和AAA (OR: 1.383; 95%CI: 1.189-1.609) 的风险之间确定了统计学上显著的积极因果关系.
- 敏感性分析证实了这些发现的可靠性.
- 在CAD,MI,尿酸水平和TAA或AD之间没有观察到显著的因果关系.
结论:
- CAD和MI已被确定为AA和AAA发展的因果风险因素.
- 这些发现表明,针对CAD/MI风险因素的干预措施也可能有利于大动脉健康.
- 尿酸水平和CAD/MI似乎在TAA发展中没有因果关系.
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