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Updated: Jun 10, 2025

Enzymatic Cascade Reactions for the Synthesis of Chiral Amino Alcohols from L-lysine
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Enzymatic Cascade Reactions for the Synthesis of Chiral Amino Alcohols from L-lysine

Published on: February 16, 2018

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通过工程双酶合系统,高效合成合性ACE抑制剂中间体 (R) -2-基-4-基酸乙烯 Ester

Yanmei Dai1, Jinmei Wang1, Zijuan Tao1

  • 1College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, 310014, China.

Bioresources and bioprocessing
|October 14, 2024
PubMed
概括

这项研究开发了一种高效的生物催化系统,用于生产 (R) 2-Hydroxy-4-phenylbutyric 酸乙烯基 ((R) -HPBE),这是ACE 抑制剂的关键中间体. 改造的大肠杆菌菌株实现了高转换率和反体过量,证明了工业可扩展性.

关键词:
双酶结合的双酶结合的碳基还原酶可以减少.融合式表达方式高密度发酵的发酵方式基质养策略 基质养策略

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