亨廷顿病的疾病成本:一个系统审查
Divya Patil1, Emily F Gorman2, T Joseph Mattingly3
1University of Maryland School of Pharmacy, Baltimore, MD, USA.
PharmacoEconomics - open
|October 14, 2024
概括
亨廷顿病 (HD) 的经济负担随着疾病的进展而显著增加,护理人员成本是最实质性的. 门诊医疗费用高于住院医疗费用,特别是在疾病早期和中期.
科学领域:
- 神经科学是一个神经科学.
- 卫生经济学 卫生经济学
- 医学社会学 医学社会学
背景情况:
- 亨廷顿病 (HD) 对患者和医疗保健系统造成了巨大的经济负担.
- 了解不同疾病阶段的经济影响对于资源分配和政策制定至关重要.
研究的目的:
- 识别和量化与亨廷顿病 (HD) 相关的费用,其进展的各个阶段.
- 分析整个疾病临床轨迹的趋势和重大成本驱动因素.
主要方法:
- 在主要数据库 (Medline,Embase,Scopus,Cochrane图书馆) 进行了系统的文献搜索.
- 包括完整文本报道了HD特定成本的文章,使用Shoulson Fahn和Barthel指数得分对早期,中期和晚期的成本进行了标准化.
- 来自美国,英国和秘鲁的五项研究被纳入数据提取和合成.
主要成果:
- 随着亨廷顿病 (HD) 的进展,住院,门诊,药物和护理费用大幅增加.
- 门诊费用大约是HD早期和中期的2.5倍高于住院费用.
- 护理人员的年度费用代表了最重要的经济负担,从6041美元 (早期阶段) 到133200美元 (晚期),各国之间观察到显著的差异.
结论:
- 门诊护理是一个关键的组成部分,相关费用超过了早期疾病阶段的住院费用.
- 亨廷顿病 (HD) 的医疗费用在晚期非线性且快速增长.
- 护理人员的负担代表了一个主要的成本,特别是在晚期的HD,突出需要一致的方法和进一步的研究在成本评估.
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