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Updated: Jun 10, 2025

A Protocol for Computer-Based Protein Structure and Function Prediction
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A Protocol for Computer-Based Protein Structure and Function Prediction

Published on: November 3, 2011

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使用ColabFold进行简单而准确的蛋白质结构预测.

Gyuri Kim1, Sewon Lee2, Eli Levy Karin3

  • 1Interdisciplinary Program in Bioinformatics, Seoul National University, Seoul, South Korea.

Nature protocols
|October 14, 2024
PubMed
概括

ColabFold-AF2使用AlphaFold2 (AF2) 模型简化了蛋白质结构预测. 该协议详细介绍了单体,复合物和形状预测的最佳实践,使生物研究更快.

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相关概念视频

Protein Folding01:25

Protein Folding

Proteins are chains of amino acids linked together by peptide bonds. Upon synthesis, a protein folds into a three-dimensional conformation, critical to its biological function. Interactions between its constituent amino acids guide protein folding, and hence the protein structure is primarily dependent on its amino acid sequence.
Protein Structure Is Critical to Its Biological Function
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Protein Folding Quality Check in the RER

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Protein and Protein Structure

Proteins are one of the most abundant organic molecules in living systems and have the most diverse range of functions of all macromolecules. Proteins may be structural, regulatory, contractile, or protective. They may serve in transport, storage, or membranes; or they may be toxins or enzymes. Their structures, like their functions, vary greatly. They are all, however, amino acid polymers arranged in a linear sequence.
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Conservation of Protein Domains Over Different Proteins

Protein domains are small structurally independent units that are part of a single amino acid chain.  Although these domains are often structurally independent, they may rely on synergistic effects to perform their functions as part of a larger protein. Protein domains may be conserved within the same organism, as well as across different organisms.
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Protein and Protein Structures

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