通过CSF PCR诊断的血清阴性布塞拉脑膜炎:报告了七起病例
Elham Jafari1, Mansoureh Togha2, Zhale Salami1,3
1Headache Department, Iranian Center of Neurological Research, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran.
BMC infectious diseases
|October 14, 2024
概括
神经结核病 (NB) 可以模仿脑中的伪瘤,表现为头痛和内压力增加的迹象. 像PCR这样的分子技术对于诊断NB至关重要,特别是当传统测试呈阴性结果时.
科学领域:
- 神经学 神经学
- 传染性疾病 传染性疾病
- 微生物学 微生物学
背景情况:
- 神经结核病 (NB) 可以表现为脑膜炎,导致头痛和脑膜症状.
- 伪瘤呈现的NB通常与淋巴细胞脑脊液 (CSF) 细胞结合有关.
- 传统的NB诊断依赖于Brucella隔离或在血液/CSF中检测抗体.
研究的目的:
- 为了研究模仿神经瘤脑部伪瘤的神经瘤的表现.
- 突出分子诊断技术在具有挑战性的NB病例中的有用性.
主要方法:
- 七名患有神经菌病的患者的病例系列.
- 临床评估包括神经学检查和神经成像 (MRI).
- 脑脊液 (CSF) 分析和布鲁塞拉PCR检测.
主要成果:
- 七个NB病例呈现出头痛和脑膜干扰.
- 五名患者表现出内高血压的迹象 (乳头,第六神经麻).
- 布鲁塞拉血清学是负的;诊断在所有情况下都通过布鲁塞拉PCR得到确认.
结论:
- 在特有地区的伪瘤大脑差异中应考虑NB.
- 分子技术 (PCR) 对于诊断NB至关重要,特别是负血清学.
- 无菌的脑脊液样本对于准确的基于分子的NB诊断至关重要.
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