5-基乙酸作为一种生物标志物,用于在急性尾炎中揭示穿孔
Arash Mohammadi Tofigh1, Majid Samsami1, Alireza Haghbin Toutounchi1
1Department of General Surgery, Imam Hosein Medical and Educational Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
BMC gastroenterology
|October 14, 2024
概括
尿液中5-氨酸 (5-HIAA) 水平升高表明,与没有穿孔的病例相比,穿孔性尾炎的可能性更高. 这种生物标志物显示出改善尾炎并发症诊断的潜力.
科学领域:
- 生物化学 生化学
- 医学诊断 医学诊断 医学诊断
- 手术病理学手术病理学
背景情况:
- 急性尾炎是一种常见的手术紧急情况.
- 及时诊断尾炎并发症,如穿孔,对于有效的治疗计划至关重要.
- 5-氨酸 (5-HIAA) 是血清素的代谢物,其水平在炎症条件下可能会发生变化.
研究的目的:
- 调查尿中5-氨酸 (5-HIAA) 水平的诊断效用,以区分穿孔和非穿孔急性尾炎.
- 评估5-HIAA作为尾炎并发症生物标志物的敏感性,特异性和准确性.
主要方法:
- 一项前性研究涉及150名被诊断患有急性尾炎的患者.
- 在手术前采集的点样中测量了尿中的5-HIAA水平.
- 根据病理和手术发现,患者被分为穿孔性尾炎和非穿孔性尾炎组.
- 使用SPSS v.27进行统计分析,以评估诊断性能指标.
主要成果:
- 在穿孔性尾炎组 (0.5 ± 0.03 mg/dl) 和无并发性急性尾炎组 (0.3 ± 0.04 mg/dl) (P < 0.001) 之间观察到尿中5-HIAA平均度的显著差异.
- 该研究报告了82%的灵敏度,62%的特异性,75%的正预测值,77%的负预测值,5-HIAA在检测穿孔尾炎的诊断准确率为88%.
- 穿孔和非穿孔组之间没有发现年龄或性别的显著差异.
结论:
- 与早期急性尾炎患者相比,穿孔性尾炎患者的尿液中5-HIAA度显著升高.
- 5-HIAA显示出作为生物标志物的潜力,有助于诊断尾炎并发症.
- 建议使用更大的样本大小进行进一步的研究,以验证这些发现.
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