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在插入3D打印可拆卸的部分PMMA假牙后,牙微生物组的转移和唾液炎症标志物的变化:试点研究

Norlela Yacob^1,2, Syarida Hasnur Safii³, Norasmatul Akma Ahmad¹

¹Department of Restorative Dentistry, Faculty of Dentistry, Universiti Malaya, Kuala Lumpur, 50603, Malaysia.

BMC oral health

|October 14, 2024

概括

与传统假牙相比,三维 (3D) 打印的假牙显示出延迟的微生物组转移和增加的细菌多样性. 这表明3D打印假牙可能会降低口腔感染的风险,例如假牙牙炎.

科学领域:

口腔微生物学口腔微生物学
生物材料科学是生物材料的科学.
牙修复牙修复牙修复牙修复牙修复

背景情况:

牙生物膜的形成涉及微生物的转移和潜在的口腔炎症.
3D打印的聚甲基甲酸 (PMMA) 假牙是传统假牙的新替代品.
调查口腔微生物组和炎症标志物对于假牙佩戴者的健康至关重要.

研究的目的:

为了比较微生物组的变化和Candida发病率在3D打印与传统制造的假牙.
在假牙插入后,分析唾液炎症标记物 (乳酸和组胺素) 的变化.
评估3D打印假牙在预防微生物失生症和口腔健康问题的潜力.

主要方法:

试点研究涉及6名3D打印或传统假牙患者,持续6周.
牙生物膜样本采集于1,3,6周,用于16S rRNA基因测序.
在基线和1,3,6周收集的唾液样本通过ELISA进行乳酸铁素 (LTF) 和基因素 (HTN) 分析.
使用PCR测定检测到氏菌的存在.

主要成果:

在3D打印和传统假牙之间观察到类似的整体微生物组成.
3D打印组在第一周显示出明显较低的链球菌水平,并在6周后显示出更大的细菌多样性.
仅在一个3D打印假牙样本中检测到菌;LTF水平在两组中都增加,而HTN仅在传统组中增加.

结论:

与传统假牙相比,3D打印假牙表现出更高的细菌多样性和延迟的微生物群转移.
3D打印假牙可能成为一个可行的替代方案,可能延迟微生物失生症并降低假牙口腔炎的风险.
3D打印假牙中的微生物多样性增加可能会减缓过渡到不平衡的口腔微生物组.

关键词:

通过3D打印打印3D打印.假牙是一种假牙.微生物组是一个微生物组.口服生物膜是一种口服生物膜.树脂树脂是一种树脂.

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