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通过细胞内质精子注射受孕的男性后代的代谢概况发生变化

Bingqian Zhang^{1,2,3,4,5,6,7,8,9,10}, Miaomiao Ban^{1,3,4,5,6,7,8,9}, Xiaojing Chen^{1,3,4,5,6,7,8,9}

¹Children and Reproductive Health, Institute of Women, Jinan, Shandong, 250012, China.

|October 14, 2024

概括

内细胞质精子注射 (ICSI) 与体外受精 (IVF) 相比,与儿童的葡萄糖和脂质水平降低有关. 父亲的体重影响了这些代谢变化,这表明体重管理可能会改善ICSI构想的儿童健康.

科学领域:

生殖医学生殖医学
儿科代谢健康儿童代谢健康
不孕症治疗方法不孕症治疗方法

背景情况:

关于儿童内细胞质精子注射 (ICSI) 的代谢影响的研究有限,大多数研究集中在神经发育结果上.
以前的研究表明,低血清脂水平与心理健康问题之间存在相关性.
这项研究调查了ICSI与体外受精 (IVF) 在男性后代的代谢影响,考虑到父亲的体重状况.

研究的目的:

与试管婴儿相比,分析ICSI对男性后代代代谢变化的影响.
检查ICSI和父亲超重/肥胖症对后代代谢健康的相互作用.

主要方法:

2006-2017年间在山东大学生殖医学中心从家庭收集的前性数据.
对子女 (0-11岁) 的BMI,血压,葡萄糖和脂质概况进行评估.
使用线性混合模型分析平均差异和95%置信区间 (CI).

主要成果:

与IVF对手相比,ICSI受孕后代 (4-11岁) 的禁食葡萄糖,总胆固醇和LDL-Cz分数显著降低.
父亲的超重/肥胖症改变了ICSI-代谢变化关系.
在超重/肥胖父亲的后代中,ICSI与较低的葡萄糖和胆固醇有关;在正常体重父亲的后代中,ICSI与较低的缩血压有关.

结论:

与IVF相比,ICSI与儿童的葡萄糖和脂质概况发生变化有关.
在ICSI后代中观察到更低的禁食葡萄糖,总胆固醇和LDL-Cz分数.
鼓励减少父亲的体重可能会改善ICSI怀孕儿童的代谢健康.

关键词:

在试管婴儿受精体外受精.在细胞体内注射精子.代谢特征代谢特征父亲的肥胖症父亲的肥胖症

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