Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Attention-Deficit/Hyperactivity Disorder01:30

Attention-Deficit/Hyperactivity Disorder

47
Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by persistent inattention, hyperactivity, and impulsivity. It affects approximately 5-8% of children globally, with around 60-70% of cases persisting into adulthood. ADHD has significant implications for educational attainment, social interactions, and occupational success.
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
47
Criteria for Causality: Bradford Hill Criteria - II01:28

Criteria for Causality: Bradford Hill Criteria - II

221
The Bradford Hill criteria serve as guidelines for establishing causative links in epidemiological research. Beyond Strength, Consistency, Specificity, and Temporality, key criteria also include Biological Gradient, Plausibility, Coherence, Experiment, and Analogy. These principles assist scientists in assessing the likelihood of causation in complex biological contexts. Below is a summary of these concepts:
221
Autism Spectrum Disorder01:19

Autism Spectrum Disorder

72
Autism spectrum disorder (ASD) is a neurodevelopmental condition marked by persistent deficits in social communication and interaction alongside restrictive and repetitive behaviors or interests. ASD is sometimes accompanied by intellectual impairment.
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.
72
Causality in Epidemiology01:21

Causality in Epidemiology

324
Causality or causation is a fundamental concept in epidemiology, vital for understanding the relationships between various factors and health outcomes. Despite its importance, there's no single, universally accepted definition of causality within the discipline. Drawing from a systematic review, causality in epidemiology encompasses several definitions, including production, necessary and sufficient, sufficient-component, counterfactual, and probabilistic models. Each has its strengths and...
324
Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

13.1K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
13.1K
Human Genetics01:28

Human Genetics

539
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
539

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Reply to- DNA methylation and the potential role of extracellular vesicles in epilepsy-associated atrial fibrillation.

Heart rhythm·2025
Same author

Metabolite-centric perspectives on QT prolongation: Molecular mechanisms and clinical implications beyond the parent drug.

Heart rhythm·2025
Same author

Integrative multi-omics identification and functional validation of potential targets linking metabolism-immune-colorectal cancer causal pathway.

Frontiers in immunology·2025
Same author

Aortic stenosis intricacies beyond the valve: A bidirectional Mendelian randomization study.

ESC heart failure·2025
Same author

Heritability and causality of QRS duration and chronic heart failure risk.

ESC heart failure·2025
Same author

When <i>HERG</i>-caused LQT2 encounters antisense oligonucleotide: is exon 6 skipping therapy plausible?

Frontiers in pharmacology·2025

相关实验视频

Updated: Jun 10, 2025

Author Spotlight: Exploring Autism Spectrum Disorder Symptoms in Fruit Flies &#8212; Genetic Models and Behavioral Tests
08:30

Author Spotlight: Exploring Autism Spectrum Disorder Symptoms in Fruit Flies — Genetic Models and Behavioral Tests

Published on: September 6, 2024

1.5K

ADHD,ASD和心血管疾病之间的因果关系:一个两步,两样本的门德尔随机化调查.

Zequn Zheng1, Dihui Cai2

  • 1First Affiliated Hospital of Shantou University Medical College, Guangdong, China.

Journal of attention disorders
|October 15, 2024
PubMed
概括

注意缺陷多动症 (ADHD) 和自闭症谱系障碍 (ASD) 与心血管疾病 (CVD) 风险增加有关. 这项研究证实了因果关系,并确定了针对性干预的吸烟和肥胖等调解因素.

科学领域:

  • 神经发育障碍 神经发育障碍
  • 心血管流行病学心血管流行病学
  • 遗传流行病学遗传流行病学

背景情况:

  • 观察性研究表明ADHD,ASD和心血管疾病 (CVD) 之间存在联系.
  • 因果关系和调解因素仍然不清楚.
  • 这项研究调查了ADHD和ASD对心血管疾病风险的因果关系.

研究的目的:

  • 为了检查ADHD,ASD和心血管疾病风险之间的因果关系.
  • 确定ADHD,ASD和心血管疾病之间的关联中介因素.
  • 为患有ADHD或ASD的个体提供有针对性的干预信息.

主要方法:

  • 使用大规模GWAS总结统计的双样本孟德尔随机化 (MR).
  • 使用两步MR和多变量MR的调解因素的探索.

主要成果:

  • ADHD与冠状动脉疾病,心力衰竭和大动脉中风的风险增加有关.
  • 自闭症与心房动和心力衰竭的风险增加有关.
  • 吸烟,阿片类药物使用,甘油三,教育,收入,贫困和肥胖是潜在的调解因素.

结论:

关键词:
更多关于 ADHD ADHD 的文章门德尔的随机化自闭症谱系障碍 自闭症谱系障碍心血管疾病心血管疾病有关因果关系的因果关系

更多相关视频

Comparing Eye-tracking Data of Children with High-functioning ASD, Comorbid ADHD, and of a Control Watching Social Videos
05:32

Comparing Eye-tracking Data of Children with High-functioning ASD, Comorbid ADHD, and of a Control Watching Social Videos

Published on: December 7, 2018

8.9K
Generalized Psychophysiological Interaction PPI Analysis of Memory Related Connectivity in Individuals at Genetic Risk for Alzheimer's Disease
09:38

Generalized Psychophysiological Interaction PPI Analysis of Memory Related Connectivity in Individuals at Genetic Risk for Alzheimer's Disease

Published on: November 14, 2017

14.8K

相关实验视频

Last Updated: Jun 10, 2025

Author Spotlight: Exploring Autism Spectrum Disorder Symptoms in Fruit Flies &#8212; Genetic Models and Behavioral Tests
08:30

Author Spotlight: Exploring Autism Spectrum Disorder Symptoms in Fruit Flies — Genetic Models and Behavioral Tests

Published on: September 6, 2024

1.5K
Comparing Eye-tracking Data of Children with High-functioning ASD, Comorbid ADHD, and of a Control Watching Social Videos
05:32

Comparing Eye-tracking Data of Children with High-functioning ASD, Comorbid ADHD, and of a Control Watching Social Videos

Published on: December 7, 2018

8.9K
Generalized Psychophysiological Interaction PPI Analysis of Memory Related Connectivity in Individuals at Genetic Risk for Alzheimer's Disease
09:38

Generalized Psychophysiological Interaction PPI Analysis of Memory Related Connectivity in Individuals at Genetic Risk for Alzheimer's Disease

Published on: November 14, 2017

14.8K
  • 这项MR研究证实了ADHD,ASD和心血管疾病之间的因果关系.
  • 强调需要对患有多动症或ASD的个体进行心血管监测.
  • 建议针对已识别的调解因素进行干预,以减少心血管疾病事件.