精液等离子体微生物组,精子参数和冷保存在一个健康的肥沃人口
Longlong Fu1, Yuanlei Lou2, Ying Guo1
1Reproductive Health Research Centre, National Research Institute for Family Planning, Beijing, China.
Frontiers in microbiology
|October 15, 2024
概括
肥沃男性的精子血微生物组会影响精子质量和精子冷保存的成功. 特定的微生物与精子参数和冷后恢复相关,突出显示了微生物群在生殖健康中的作用.
科学领域:
- 微生物学 微生物学
- 生殖生物学 生殖生物学
- 基因组学就是基因组学.
背景情况:
- 以前被认为是无菌的人类组织现在已知可以容纳各种微生物群落.
- 精液等离子体微生物组学是一个研究精液微生物组成的新兴领域.
- 这项研究探讨了精液微生物,精液参数和精液冷存活之间的联系.
研究的目的:
- 为了描述健康,肥沃的男性精液等离子体中的微生物多样性.
- 调查精液等离子体微生物群与精液质量参数之间的相关性.
- 评估冷保存对精液等离子体微生物组合的影响及其与精子冷耐受性的关系.
主要方法:
- 16S rRNA基因测序用于分析精液等离子体中的微生物群落.
- 确定了AMPLICON序列变异 (ASV) 和主导的属.
- 斯皮尔曼相关性被用来评估微生物组成和精液参数之间的关系.
- 配对的t测试比较了冷保存前后的微生物组概况.
主要成果:
- 在精液等离子中占主导地位的类系是Firmicutes,Bacteroidota,Proteobacteria,Actinobacteriota和Campylobacterota.
- Porphyromonas_asaccharolytica显示出与精子度的相关性.
- 冷保存显著改变了微生物的组成,影响了像坎皮洛巴克特和穆里巴库拉ceae这样的种群.
- 包括Orynebacterium_tuberculostearicum在内的特定微生物与解后的精子运动恢复有积极的相关性.
结论:
- 精液等离子体在肥沃个体中含有独特的微生物群.
- 这种微生物群与精液质量和精子冷存活有关.
- 了解精液微生物群可以为改善辅助生殖技术和精液保存提供见解.
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