毒素引起的行为变化 - - 微生物失生症是缺失的环节吗?
Emese Prandovszky1, Emily G Severance1, Victor W Splan1
1Stanley Division of Developmental Neurovirology, Department of Pediatrics, School of Medicine, Johns Hopkins University, Baltimore, MD, United States.
Frontiers in cellular and infection microbiology
|October 15, 2024
概括
毒素菌感染影响全球三分之一的人口,并与行为变化有关. 本综述探讨了肠道微生物组中断在慢性T. gondii感染和相关行为改变中的潜在作用.
科学领域:
- 寄生虫学的寄生虫学
- 神经科学是一个神经科学.
- 微生物学 微生物学
背景情况:
- 毒淋巴菌 (T. gondii) 是一种广泛传播的细胞内原生动物,能够感染大多数哺乳动物细胞.
- 它建立了慢性感染,通过在肌肉和大脑中形成囊,持续宿主的一生.
- 淋巴菌感染影响了世界三分之一的人口,对免疫力低下的人构成风险,并可能导致行为变化.
研究的目的:
- 审查解释与T. gondii感染相关的行为变化的假设.
- 提出和调查慢性T. gondii感染,肠道微生物失调症和行为改变之间的联系.
- 为了突出显示慢性T. gondii感染期间肠道微生物群的不充分表征的变化.
主要方法:
- 对T. gondii诱导的行为变化现有假设的文献综述.
- 探索最近的研究,将肠道微生物组与T. gondii感染联系起来.
- 分析微生物失生症在慢性感染阶段的潜在作用.
主要成果:
- 已知急性T. gondii感染会导致显著的肠道微生物失调.
- 有证据表明,T. gondii感染与人类和动物的宿主行为改变之间存在联系.
- 连接慢性T. gondii感染,肠道微生物组变化和行为变化的特定机制在很大程度上仍未被阐明.
结论:
- 肠道微生物失调是一种潜在的,新的机制,是慢性T. gondii感染的行为变化的基础.
- 需要进一步的研究,以充分描述慢性T. gondii感染期间肠道微生物组的变化.
- 了解这种联系可能会为T. gondii的发病和宿主-寄生虫相互作用提供新的见解.
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