在神经炎光学谱系障碍和多发性硬化症中,认知功能和大脑磁共振成像资料
Fereshteh Ashtari1, Pouran Najarzadeh1, Vahid Shaygannejad1
1Department of Neurology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
概括
神经脊髓炎光学谱系障碍 (NMOSD) 和多发性硬化症 (MS) 患者在处理速度,工作记忆和口语流方面表现出认知障碍. 多发性硬化症患者也表现出视觉空间记忆缺陷,表明NMOSD的潜在显微异常.
科学领域:
- 神经科学是一个神经科学.
- 免疫学 免疫学 免疫学
- 神经学 神经学
背景情况:
- 视神经炎光谱障碍 (NMOSD) 和多发性硬化症 (MS) 是中枢神经系统的炎症性脱髓化疾病.
- 认知功能障碍是MS和NMOSD中常见但经常被忽视的症状.
- 了解不同的认知特征及其与大脑变化的关系对于患者管理至关重要.
研究的目的:
- 为了比较NMOSD和MS患者之间的认知表现.
- 在这些患者群体中,研究认知缺陷和大脑体积变化之间的关系,包括病变负荷和特定大脑区域缩.
主要方法:
- 一项历史性队列研究包括29名多发性硬化患者,31名NMOSD患者和20名健康对照 (HC).
- 神经心理评估使用多发性硬化症认知功能的最小评估 (MACFIMS) 电池进行.
- 磁共振成像 (MRI) 用于评估MS和NMOSD患者的大脑体积和病变负担.
主要成果:
- 与HC相比,MS和NMOSD患者在符号数字模式测试和受控口语词汇协会测试中得分明显较低.
- 在简要视觉空间记忆测试中,MS患者的表现比NMOSD患者差.
- 认知得分与MS患者的总脑损伤和thalamic体积相关,而NMOSD患者显示灰质体积和口头学习,以及损伤负载和处理速度/口头记忆之间的相关性.
结论:
- 患有NMOSD和MS的患者在信息处理速度,工作记忆和口语流性方面经历了损害.
- 在这个队列中,视觉空间记忆缺陷是MS患者特有的.
- 尽管NMOSD患者的脑损伤负担和乳头缩较小,但仍然存在认知障碍的风险,可能是由于显微结构异常.
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