埃德蒙顿虚弱度表作为查虚弱度的评分在瘤老年病学
Julia De Schrevel1, Clémentine Faucon1, François-Xavier Sibille2,3
1Geriatric Department, Hôpital Universitaire de Bruxelles, Brussels, Belgium.
Frontiers in medicine
|October 15, 2024
概括
埃德蒙顿脆弱度量 (EFS) 可靠地识别了G8工具已经选的老年癌症患者的脆弱性. 此外,EFS还独立预测了这一群体的一年死亡率.
科学领域:
- 老年瘤学 老年瘤学
- 瘤老年病学 瘤老年病学
- 癌症患者评估 癌症患者评估
背景情况:
- 建议对老年癌症患者进行综合老年评估 (CGA),但需要大量的时间.
- 八国集团工具对脆弱性进行选,以识别需要CGA的患者.
- 埃德蒙顿虚弱度表 (EFS) 已被验证用于手术前的虚弱,但在瘤老年病学方面没有充分研究.
研究的目的:
- 检查EFS在老年癌症患者的附加价值已经被G8确定为脆弱的癌症患者.
- 分析EFS与CGA和一年死亡率的关联.
主要方法:
- 对380名70岁以上的新癌症诊断患者进行了回顾性研究,G8对其进行了潜在的脆弱查,并接受了CGA.
- 分析EFS与CGA组件的关联性和1年死亡率,经相关因素调整.
主要成果:
- 在EFS中,86.58%的患者被确定为虚弱,显示出与CGA组件的显著关联 (r=0.64,p<0.001).
- 在调整后,EFS与CGA (p<0.0001) 和并发症 (p=0.004) 独立相关.
- 在一年内死亡的患者的EFS平均得分明显高 (p<0.0001).
- 在根据癌症类型和阶段进行调整后,EFS独立预测了一年死亡率 (OR 1.17;95% CI 1.08-1.28;p<0.001).
结论:
- EFS是一种可靠的工具,用于预测由G8预先选择为脆弱的老年癌症患者的脆弱性 (通过CGA确定).
- 在这一群体中,EFS是一年死亡率的独立预测指标.
- 需要进一步的研究来验证正常G8分数的患者的EFS性能.
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