意大利的非酒精性型肝炎患者表征和现实世界管理方法
Elisabetta Bugianesi1, Luca Miele2,3, Giovanna Donnarumma4
1Division of Gastroenterology, Department of Medical Sciences, University of Torino, AOU Città della Salute e della Scienza, Torino, Italy.
Pragmatic and observational research
|October 15, 2024
概括
意大利患有非酒精性脂肪肝炎 (NASH) 的患者经常患有肥胖和多种并发症. 目前在意大利对NASH的诊断和治疗经常不遵循指导方针,这表明需要改进护理策略.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 胃肠病学 胃肠病学
- 内分泌学 在内分泌学.
背景情况:
- 非酒精性脂肪肝炎 (NASH) 影响了意大利人口的4-6%.
- 意大利对NASH患者人口统计和护理途径的了解有限.
研究的目的:
- 为了鉴定意大利NASH或疑似NASH患者的特征.
- 描述意大利NASH患者目前的管理方法.
主要方法:
- 意大利内分泌学家和胃肠道学家的横截面调查 (2018年1月至3月).
- 对380名患有NASH或怀疑NASH的患者的数据进行描述性分析.
- 医生填写了关于患者特征和治疗的问卷.
主要成果:
- 该研究包括380名患者 (平均年龄58.5岁,平均BMI为31.8公斤/米2).
- 肥胖 (81%) 和2型糖尿病 (62%) 的高患病率;70%的人有≥3种并发症.
- 诊断和治疗往往偏离了指导方针;维生素E和GLP-1受体激动剂是指导方针推的最常见的治疗方法 (分别为13%).
结论:
- 意大利NASH患者表现出显著的肥胖和并发症负担.
- 意大利的诊断和治疗模式往往不符合既定指南.
- 在意大利,对于NASH的优化,有针对性的诊断和治疗策略有明显的未满足需求,以改善患者的治疗结果.
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