在糖尿病患者中预测结直肠癌的风险,使用随机生存森林引导方法
Sarah Tsz Yui Yau1, Chi Tim Hung1, Eman Yee Man Leung1
1JC School of Public Health and Primary Care, The Chinese University of Hong Kong, Hong Kong, Hong Kong SAR, China.
Frontiers in oncology
|October 15, 2024
概括
一个新的风险评分可以预测糖尿病患者的结肠直肠癌 (CRC),使用年龄,腰部和部的比率以及血清肌素. 血清肌素升高可能表明CRC风险增加,建议进一步研究功能以进行查.
科学领域:
- 在瘤学瘤学.
- 内分泌学 在内分泌学.
- 腎臟病學 (nephrology) 是一種醫學.
背景情况:
- 大肠直肠癌 (CRC) 是全球领先的癌症.
- 糖尿病和CRC有共同的生活方式风险因素,如肥胖和饮食.
- 在糖尿病患者中开发CRC的预测模型至关重要.
研究的目的:
- 在糖尿病患者中开发结直肠癌 (CRC) 预测的风险评分系统.
- 通过使用常规医疗记录,识别CRC风险的关键预测因素.
主要方法:
- 使用香港电子健康记录进行的回顾性队列研究.
- 从2010年到2019年,患者的鉴定和随访.
- 通过随机生存森林和Cox回归来进行预测器选择,用于建模.
主要成果:
- 分析了386,325名糖尿病患者的队列,其中4,199名患有CRC.
- CRC的发病率为每1000人年1.93人.
- 评分系统中的关键预测因素包括年龄,腰比和血清肌素;高血清肌素与CRC风险有显著关联.
结论:
- 功能障碍,通过血清肌水平升高表明,可能是糖尿病患者CRC的重要危险因素.
- 开发的风险评分系统有助于在这个人群中预测CRC.
- 需要进一步的研究来探索功能在糖尿病患者CRC查建议中的作用.
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