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库尔库明/清代组合在患有活跃性性结肠炎的儿童中的疗效:一个多中心回顾性队列研究
Nurit Loberman Nachum1,2, Nir Salomon3, Anat Yerushalmy-Feler2,4
1Pediatric Gastroenterology and Nutrition Unit, Edmond and Lily Safra Children's Hospital, Tel Hashomer, Israel.
库尔库明和清代 (CurQD) 组合疗法在治疗儿科炎症性肠病 (IBD) 中表现有前途. 这种草药治疗有效地减少了儿童性结肠炎 (UC) 或IBD未分类 (IBD-U) 的疾病活动和炎症.
科学领域:
- 胃肠病学和肝病学
- 儿科炎症性肠病 (IBD) 是一种疾病.
- 补充和替代医学 补充和替代医学
背景情况:
- 黄素和清代 (QD) 是草本提取物,在治疗炎症性肠病 (IBD) 中已被证明是有效的.
- 自2016年以来,黄素与QD (CurQD) 的组合已用于治疗活性性结肠炎 (UC).
- 本研究研究CurQD在患有轻度至中度UC或IBD未分类 (IBD-U) 的儿科患者的使用情况.
研究的目的:
- 评估CurQD治疗在被诊断为轻度至中度UC或IBD-U的儿童中的有效性和安全性.
- 评估CurQD作为儿科IBD管理的潜在治疗选择.
主要方法:
- 一项多中心回顾性研究包括30名儿童 (≤18岁) 在2017年至2021年期间接受CurQD治疗.
- 使用儿科UC活动指数 (PUCAI) 和便calprotectin (FC) 水平来评估疾病活性.
- 主要结局包括PUCAI显著下降,FC正常化或FC水平大幅下降.
主要成果:
- 在26名患者中,CurQD治疗使平均PUCAI从31.3显著降低到10.9 (p < 0.001).
- 分别在11/12和7/12的患者中观察到FC正常化或反应,FC的中位数从749降至39μg/gm (p = 0.04).
- 在8个月的中位随访期间,33%的患者经历了爆发,其中10/18的患者在继续治疗时获得了临床反应或缓解.
结论:
- 在儿童轻度至中度UC/IBD-U中,CurQD证明了作为诱导和维持缓解的附加疗法的潜在有效性和安全性.
- 这些发现表明,CurQD可以成为儿科IBD常规管理策略的有价值组成部分.
- 需要进一步的前性研究来证实CurQD在这个人群中的长期疗效和安全性.
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