周围NK细胞计数预测乳腺癌患者接受新辅助化疗的反应和预后
Chao Zhang1, Fengjia Wu1, Xiuqing Lu1
1State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-Sen University Cancer Center, Guangzhou, China.
Frontiers in immunology
|October 15, 2024
概括
周围血液自然杀手 (NK) 细胞数量可以预测乳腺癌 (BC) 患者的新辅助化疗 (NAT) 反应和预后. 较高的NK细胞水平与更好的结果相关,建议在预测模型中使用它们.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 生物统计学 生物统计学
背景情况:
- 周围血液淋巴细胞子集反映了免疫状态,影响瘤微环境和新辅助化疗 (NAT) 疗效.
- 了解这些标志物对于优化乳腺癌 (BC) 治疗策略至关重要.
研究的目的:
- 研究外围血液淋巴细胞子集与乳腺癌患者中NAT的疗效和预后之间的关联.
- 为了确定NAT反应和生存结果的预测标记.
主要方法:
- 对接受NAT的230名乳腺癌患者的回顾性分析.
- 卡普兰-梅尔曲线用于生存概率,多变量后勤和考克斯回归用于预测分析.
- 构建和验证名录以预测NAT反应,整体存活率 (OS) 和无复发存活率 (RFS).
主要成果:
- 较高的自然杀手 (NK) 细胞数量与较高的病理完整响应 (pCR) 率,改善的生存状况和RFS显著相关 (所有P < 0.001).
- NK细胞数量成为NAT反应,OS和RFS的独立预测因子.
- 经过验证的诺姆图表显示出良好的预测性能 (C指数:NAT响应0.786,OS 0.877,RFS 0.794).
结论:
- 周围血液NK细胞计数作为接受NAT.的乳腺癌患者的潜在预测生物标志物.
- 包含NK细胞计数的诺姆图可能有助于预测NAT反应和患者预后.
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