血清费里是肺功能障碍的危险因素,患有输血依赖性沙拉西米亚的年轻患者
Xiao Liang1, Gaohui Yang1, Lingling Shi1
1Department of Hematology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Heliyon
|October 15, 2024
概括
肺功能异常在输血依赖性沙拉西米亚 (TDT) 患者中很常见,特别是扩散功能障碍. 血清氨酸水平的升高与这些问题有显著的相关性,而血红蛋白的升高提供了保护.
科学领域:
- 血液学 血液学 血液学
- 肺部病理学 肺部病理学
- 内部医学 内部医学
背景情况:
- 有限的研究存在于输血依赖性沙拉西米亚 (TDT) 的肺功能.
- 现有研究对TDT患者的肺功能提出了相互矛盾的结果.
- 肺部并发症可以显著影响TDT患者的生活质量和预后.
研究的目的:
- 调查TDT患者肺功能异常的患病率和模式.
- 在这个人群中确定与肺功能障碍相关的潜在风险因素.
- 为了确定血清费里水平,血红蛋白度和肺功能之间的相关性.
主要方法:
- 对140名依赖输血的沙拉西米亚患者进行了回顾性研究.
- 分析肺功能测试,包括扩散能力,呼吸功能和混合功能障碍.
- 统计分析以确定血清费里,血红蛋白水平和肺功能异常之间的相关性.
主要成果:
- 在46.43%的TDT患者中检测到肺功能异常.
- 扩散功能障碍是最常见的异常 (26.43%).
- 血清费里丁水平> 2500 ng/ml与肺部异常有显著的相关性 (OR=3.187,P=0.010),而较高的血红蛋白显示出保护作用 (OR=0.966,P=0.004).
结论:
- 扩散功能障碍是TDT患者的主要肺部问题.
- 血清费里丁的升高是TDT中肺功能障碍的重要危险因素.
- 保持最佳的血红蛋白水平可能对TDT中的肺功能产生保护作用.
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