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来自卵细胞的胚胎囊,具有光滑的内分泌网膜聚合物,具有降低的euploidy率:一项回顾性队列研究

Pengcheng Kong¹, Jiaping Pan¹, Shanshan Liang¹

¹Center of Reproductive Medicine, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai, China.

Frontiers in endocrinology

|October 15, 2024

概括

卵细胞中的光滑内质网膜聚合物 (SERa) 与较低的胚胎细胞积率有关. 然而,成功怀孕和新生儿结局在从SERa(+) 或SERa(-) 卵细胞转移euploid胚胎后是可比的.

科学领域:

生殖医学生殖医学
胚胎学胚胎学
遗传学是一个遗传学.

背景情况:

在卵细胞中观察到光滑的内质网膜聚合物 (SERa).
SERa对卵细胞质量和随后的胚胎发育的影响尚未完全理解.

研究的目的:

调查SERA在卵细胞中的存在是否会影响芽细胞的欧化率.
评估SERA对受精,裂变,胚胎囊形成和怀孕结果的影响.

主要方法:

对671名患者进行了回顾性队列研究,这些患者接受了前植入基因检测 (PGT-A) 的前植入基因检测.
卵子细胞根据SERA的存在或不存在而被分类.
在不同组之间比较受精率,裂变率,胚胎细胞形成率和euploidy率.

主要成果:

在有或没有SERA的卵细胞之间,没有观察到受精,裂变或胚胎细胞形成率的显著差异.
与没有SERA (51.2%54.5%) 相比,来自有SERA的卵细胞的芽细胞显示出明显较低的euploidy率 (39.3%).
怀孕和新生儿的结局是相似的,无论SERA是否存在于用于euploid胚胎移植的卵细胞中.

结论:

卵细胞中SERA的存在与由此产生的胚胎囊中的euploidy率降低有关.
尽管euploidy的发育率较低,但euploid胚胎从SERa(+) 卵细胞转移会导致相似的繁殖成功.
在卵细胞中SERa的存在似乎不会在选择euploid胚胎时对怀孕和新生儿的结果产生负面影响.

关键词:

胚胎细胞囊中的胚胎囊.欧化率是如何计算的卵细胞形态卵细胞形态在植入前进行遗传检测.平滑的内质网膜聚合物.

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