雌激素介导的孕产妇效应和权衡:在野生猫中产后荷尔蒙发育,生长和生存率
Charli S Davies1,2, Caroline L Shearer1,3, Lydia K Greene1,2,3
1Department of Evolutionary Anthropology, Duke University, Durham, NC, United States.
Frontiers in endocrinology
|October 15, 2024
概括
孕产妇的雄激素会影响水母猫后代的发育,影响激素水平,生长和生存. 在主导性雌性中阻断产前雄激素改善了后代IGF-1和生存率,突出了母亲对发育的影响.
科学领域:
- 内分泌学 在内分泌学.
- 发展生物学 发展生物学
- 行为生态学 行为生态学
背景情况:
- 哺乳动物的发育是由类固醇激素如 (T) 和生长激素/胰岛素类生长因子-1 (IGF-1) 系统调节的.
- 这些系统促进了性别差异化,男性偏见的增长,通常与健康的权衡.
- 野生水猫在怀孕期间表现出自然高的母性雌激素水平,使它们成为研究母性影响的独特模型.
研究的目的:
- 为了研究母体雌激素暴露对野生猫后代发育的影响.
- 检查产前雄激素水平如何影响后代的生殖激素,生长和生存率.
- 测试实验性地改变母亲的雄激素是否会影响发育模式和权衡.
主要方法:
- 从主导对照 (高T),附属对照 (低T) 和主导治疗 (抗雄激素阻塞) 的母亲的男性和女性后代进行比较.
- 评估后代androstenedione (A4),T,雌激素 (E2),IGF-1,成长 (1个月至1年),以及生存率.
- 检查了对母体雄激素的规范性和实验性诱导变化的影响.
主要成果:
- 后代在T和IGF-1中表现出性别差异,早期男性T偏差在青春期消失.
- 非典型的发现包括A4和E2中没有性别差异,以及女性偏见的IGF-1.
- 母亲的治疗影响了后代的T,E2,IGF-1和体重;受阻的雄激素后代的IGF-1峰值和更好的生存率.
结论:
- 孕产妇的影响显著影响水母猫后代的发育,产前雄激素改变产后生理.
- 高水平的母体雌激素可能会带来竞争优势,但可能会带来成本,如降低IGF-1和生存率.
- 这些发现强调了合作育种动物的多样性进化途径,以及自然内分泌变异的重要性.
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