在第三手术中使用德克塞托托马的止痛效果:系统性审查和元分析
Bishwa Prakash Bhattarai1, Diane Isabel Selvido2,3, Dinesh Rokaya4,5
1Department of Oral Biology, Faculty of Dentistry, University of Oslo, Norway.
Journal of dental anesthesia and pain medicine
|October 15, 2024
概括
德克斯基托 (Dexketoprofen trometamol,DT) 有效地缓解了第三手术后的疼痛,特别是在前6小时内. 与其他止痛药相比,25毫克的DT剂量在早期的术后阶段提供了优越的疼痛控制.
科学领域:
- 药理学 药理学是指药理学的学科.
- 在口腔外科手术.
- 疼痛管理 疼痛管理
背景情况:
- 第三手术经常导致显著的术后疼痛.
- 有效的疼痛管理对于患者的康复和满意度至关重要.
- 目前的止痛药选择在有效性和耐受性方面各不相同.
研究的目的:
- 为了比较德克斯基托洛 (Dexketoprofen trometamol,简称DT) 与其他止痛药的止痛效果,在第三提取后治疗疼痛.
- 评估结果,包括疼痛强度,疼痛缓解,需要救援药物和耐受性.
主要方法:
- 进行了随机对照试验 (RCT) 的系统审查和元分析.
- 在PubMed,Scopus和Web of Science数据库中进行了搜索.
- 包括专注于第三手术的研究,将DT与活性对照进行比较,评估疼痛缓解 (SPID,TOTPAR),救援药物时间和耐受性.
主要成果:
- 涉及660名患者的4个RCT (365名DT,295名对照) 符合纳入标准.
- 德克斯基托托美 (25毫克) 在第六个术后小时显著改善了疼痛缓解 (SPID: MD,0.33; P=0.01; TOTPAR: MD,0.41; P=0.02).
- 在第八个小时没有观察到任何显著的差异,对于时间来拯救药物,或DT和对照组之间的耐受性.
结论:
- 德克斯基托托美 (25毫克) 是第三手术后管理早期术后疼痛的一个有价值的替代品.
- 在提取后的最初几个小时内,DT在快速缓解疼痛方面具有特别的益处.
- 进一步的研究可能会探索长期疗效和最佳剂量策略.
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