在成功治疗牛皮的患者中,动脉功能被保留
Eva Klara Merzel Šabović1,2, Tadeja Kraner Šumenjak3, Mojca Božič Mijovski4
1Department of Dermatovenerology, University Medical Centre Ljubljana, Ljubljana, Slovenia.
Science progress
|October 15, 2024
概括
在年轻成年人中,有效的牛皮治疗可以预防动脉功能障碍并降低心血管风险. 早期介入抗皮病疗法似乎可以提供心脏保护性益处,即使有肥胖等危险因素.
科学领域:
- 心血管健康 心血管健康
- 皮肤病学 皮肤病学
- 血管生物学 血管生物学
背景情况:
- 牛皮与内皮功能障碍和动脉样硬化有关.
- 牛皮的炎症是心血管风险的可疑驱动因素.
- 心血管疾病是牛皮患者的主要关注点.
研究的目的:
- 在年轻的牛皮患者中调查内皮细胞功能,动脉硬性和内皮细胞激活标志物.
- 评估有效的抗 psoriatic 治疗对心血管风险因素的影响.
- 为了确定早期和有效的牛皮治疗是否能减轻动脉功能障碍.
主要方法:
- 对80名年轻牛皮患者 (PASI 90) 和20名对照人进行的横截面研究.
- 通过流介导扩张评估内皮功能.
- 测量了动脉硬度 (脉冲波速度,动脉硬度) 和生物标志物 (ICAM-1,VCAM-1,选择蛋白,GDF-15,TRAIL).
主要成果:
- 在接受治疗的牛皮患者和对照人群之间,内皮功能或动脉硬度没有显著差异.
- 循环内皮细胞激活生物标志物在不同组之间是可比的.
- 有效的抗牛皮治疗没有对血管参数产生有害影响.
结论:
- 早期和有效的牛皮治疗可以预防牛皮相关的动脉功能障碍.
- 抗症疗法可能会产生心脏保护作用,降低心血管风险.
- 这表明,积极治疗牛皮有好处,以保护心血管健康.
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