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Updated: Jun 10, 2025

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使用记者基因测试来选和识别调节雌激素受体活动的化学化合物

Masato Ooka1, Srilatha Sakamuru1, J David Furlow2

  • 1National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland.

Current protocols
|October 15, 2024
PubMed
概括

开发了高通量选方法,以快速测试调节雌激素受体α (ERα) 的化合物. 这些测试可以有效地识别和确认ERα调节剂用于制药应用.

关键词:
雌激素受体阿尔法受体是什么雌激素受体记者基因检测试验量化高吞吐量选 量化高吞吐量选

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Reporter Genes

Reporter genes are a type of protein-coding gene that are often tagged to a gene of interest. Once inside a target cell, reporter genes usually produce visually identifiable characteristics like fluorescence and luminescence when expressed along with the gene of interest. Thus, reporter genes “report” the presence or absence of genes of interest in an organism, determine the gene expression pattern, or track the physical location of a DNA segment or protein in the cell.
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