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Updated: Jun 10, 2025

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探索发育清除和对成人和期内新生儿烯糖醇暴露的影响,使用生理学基础的药物动力学建模

Olusola Olafuyi1, Robin Michelet2,3, Michael Garle1

  • 1Division of Physiology, Pharmacology and Neuroscience, School of Life Sciences, University of Nottingham, Nottingham, UK.

Journal of clinical pharmacology
|October 15, 2024
PubMed
概括

当酒精脱酶 (ADH) 途径和时,烯基醇 (PG) 积累和毒性可能发生. 这项研究开发了模型,以根据剂量预测成人和新生儿的PG清除和毒性.

关键词:
辅助剂是一种辅助剂.新生儿们的新生儿人类的本体生长过程 (ontogeny)基于生理学的药理动力学.烯基甘醇是一种基醇.

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