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抗阿美西宁的疟疾耐药性

N J White^1,2, K Chotivanich^1,3

¹Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.

Clinical microbiology reviews

|October 15, 2024

概括

在Plasmodium falciparum疟疾中抗素耐药性正在全球蔓延,威胁到治疗疗效. 应对这种情况的策略包括部署三重甲美西宁组合疗法和减少单一疗法的使用.

科学领域:

热带医学热带医学
传染性疾病传染性疾病
寄生虫学的寄生虫学

背景情况:

素抗疟药对疟疾治疗至关重要.
杆菌 (Plasmodium falciparum) 中的素耐药性是一个日益严重的全球性问题.
抵抗已经从东南亚蔓延到南美和东非.

研究的目的:

审查当前的状态和影响在Plasmodium falciparum.艺术素耐药性.
突出阿美西宁耐药性的遗传基础和临床表现.
讨论管理和延迟更高抵抗水平出现的策略.

主要方法:

对科学文献的综述关于抗素的耐药性.
分析与耐药性相关的地理分布和遗传突变.
对治疗结果和公共健康的临床影响的评估.

主要成果:

抗素耐药性与PfKelch基因的突变有关.
耐药性导致对环阶段寄生虫的疗效降低,寄生虫清除速度减慢.
在包括东非在内的新地理区域出现了抗药性.
减少的游戏细胞杀伤性活性会影响疟疾的传播.

结论:

抗素耐药性对疟疾控制工作构成重大威胁.
维持基于美素的组合疗法 (ACT) 的高治愈率至关重要.
为了保持治疗疗效,需要使用三重ACT和明智使用抗疟药等策略.
对高风险患者来说,需要改善超寄生病血的诊断方法.

关键词:

原菌 (Plasmodium falciparum) 是一种有毒的病毒.抗疟疾药物的使用.艺术品中的艺术品.药物耐药性的演变药物耐药性的演变疟疾疟疾是一种疾病.

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