使AlphaFold2WntDIX-DIX

Zehua Wen1, Lei Wang1, Shi-Wei Liu1

  • 1College of Chemical Engineering, Sichuan University of Science and Engineering, Zigong 64300, China.

Cells
|October 15, 2024
PubMed
概括

Wnt信号依赖于DIX域互动. AlphaFold2和PRODIGY预测了结合亲和性,揭示了Axin2和Dvl1同分体更强,异分体通常表现出更高的亲和力,澄清了Wnt通路机制.

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