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Updated: Jun 10, 2025

Reporter-based Growth Assay for Systematic Analysis of Protein Degradation
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调查p21乌比奎丁独立的Degron揭示了一个调节p21降解和功能的双Degron模块

Marianna Riutin1, Pnina Erez1, Julia Adler1

  • 1Department of Molecular Genetics, Weizmann Institute of Science, Rehovot P.O. Box 26, Israel.

Cells
|October 15, 2024
PubMed
概括

像p21这样的内在无序的蛋白质被20S蛋白质组降解,而不依赖于ubiquitin. 一个特定的p21区域 (RRLIF框) 针对它进行降解,影响细胞周期和衰老.

关键词:
20S蛋白质酶向向的目标在CDKN1A和p21WAF1/Cip1降解过程中.在无素独立的降解过程中.

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