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Updated: Jun 10, 2025

In Vitro Analysis of E3 Ubiquitin Ligase Function
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CTLA4的快速周转与可逆无处不在的复杂架构有关

Pei Yee Tey1, Almut Dufner2,3, Klaus-Peter Knobeloch2,3

  • 1Biochemistry, Cell and Systems Biology, Institute of Systems, Molecular and Integrative Biology, University of Liverpool , Liverpool, UK.

The Journal of cell biology
|October 15, 2024
PubMed
概括

细胞毒性T-淋巴细胞关联蛋白4 (CTLA4) 降解通过无处不在和二双酶USP8.8进行调节. 丢失USP8加速CTLA4的无处不在和周转,影响其细胞水平和外体细胞分泌.

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